Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp

Tacrolimus in Solution as an Option to Inflammatory Conditions of the Scalp

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Introduction: Several dermatological diseases lead to inflammatory conditions of the scalp.Most of these afflictions are recalcitrant read more and require long term maintenance treatment.Objectives: We present a case series where topical tacrolimus was used in a solution vehicle for these conditions.

Methods: A total of 22 patients (aged 24-90 years) with confirmed diagnosis of lichen planus pilaris (LPP),discoid lupus (DL),frontal fibrosing alopecia (FFA),erosive pustulosis of the scalp (EPS) or folliculitis decalvans (FD) were evaluated and treated with tacrolimus solution (0.1%) applied twice daily for 1 month, then once daily for another month and alternate days for 4 months.Efficacy was evaluated by an investigator global assessment,clinical and dermoscopic evaluation at weeks 4,8 and 24.

The safety assessment included monitoring of all adverse events.Results: The study included 13 patients with LPP, 2 with DL, 2 with FD, 2 with EPS and 3 with AFF.After 1 month, 14 patients (63.

6%) had a good response and 7 (31.8%) had excellent response.After 2 months, 16 patients mpu63zm/a (72.

7%) had excellent response, and this response was persistent after 6 months of treatment.Conclusions: Tacrolimus in solution,even if not yet commercially available,was an effective and well tolerated alternative for the maintenance treatment of inflammatory conditions of the scalp.